EFEMP1 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IP |
---|---|
Primary Accession | Q12805 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 54641 Da |
Gene ID | 2202 |
---|---|
Other Names | EFEMP1 |
Dilution | WB~~1/500-1/1000 IHC~~1/50-1/100 |
Format | Liquid |
Name | EFEMP1 |
---|---|
Synonyms | FBLN3, FBNL |
Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
Cellular Location | Secreted, extracellular space, extracellular matrix. Note=Localizes to the lamina propria underneath the olfactory epithelium {ECO:0000250|UniProtKB:O35568} |
Tissue Location | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina |
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