Annexin 2 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP |
---|---|
Primary Accession | P07355 |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 38604 Da |
Gene ID | 302 |
---|---|
Other Names | ANXA2 |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | ANXA2 |
---|---|
Synonyms | ANX2, ANX2L4, CAL1H, LPC2D |
Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). |
Cellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism |
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