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EphA6 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - EphA6 Antibody AP7611d
    Western blot analysis of EphA6 (arrow) using rabbit polyclonal EphA6 Antibody (Cat.#AP7611d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EPHA6 gene (Lane 2) (Origene Technologies).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UF33
Other Accession Q62413
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 116379 Da
Additional Information
Gene ID 285220
Other Names Ephrin type-A receptor 6, EPH homology kinase 2, EHK-2, Epha6, Ehk-2, Ehk2
Target/Specificity This EphA6 antibody is generated from rabbits immunized with his fusion recombinant protein of human EPHA6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEphA6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPHA6
Synonyms EHK2, HEK12
Function Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in brain and testis.
Research Areas
Citations (0)
citation

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Background

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

References

Lee, A.M., et al., DNA Cell Biol. 15(10):817-825 (1996).

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$ 365.00
$ 140.00
Cat# AP7611d
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