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LUM Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P51884 |
| Other Accession | P51886, P51885 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38429 Da |
| Antigen Region | 64-91 aa |
| Gene ID | 4060 |
|---|---|
| Other Names | Lumican, Keratan sulfate proteoglycan lumican, KSPG lumican, LUM, LDC, SLRR2D |
| Target/Specificity | This LUM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-91 amino acids from the N-terminal region of human LUM. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LUM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LUM |
|---|---|
| Synonyms | LDC, SLRR2D |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Cornea and other tissues. |
Provided below are standard protocols that you may find useful for product applications.
Background
LUM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, this protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. The protein is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
References
Wang,P., Li,S. Invest. Ophthalmol. Vis. Sci. 50 (4), 1546-1551 (2009)
Matsuda,Y., Yamamoto,T. Int. J. Oncol. 33 (6), 1177-1185 (2008)
Kelemen,L.E., Couch,F.J. Breast Cancer Res. 10 (6), R98 (2008)
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