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> home > Products > Primary Antibodies > Antibody Collections > Phospho Antibodies > Phospho-Rb2 p130 (Ser952) Rabbit mAb
Phospho-Rb2 p130 (Ser952) Rabbit mAb
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Application 
| WB, IHC-P, IHC-F, ICC |
|---|---|
| Primary Accession | Q08999 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 128367 Da |
| Gene ID | 5934 |
|---|---|
| Other Names | RBL2 |
| Dilution | WB~~1/500-1/1000 IHC~~1/50-1/100 IF~~1/50-1/200 |
| Format | Liquid |
| Name | RBL2 |
|---|---|
| Synonyms | RB2 |
| Function | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Cellular Location | Nucleus. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP76012
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