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PUMA Rabbit mAb

     
  • WB - PUMA Rabbit mAb AP75977
    detail
  • IHC - PUMA Rabbit mAb AP75977
    detail
  • IF - PUMA Rabbit mAb AP75977
    detail
  •  - PUMA Rabbit mAb AP75977
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F, ICC
Primary Accession Q9BXH1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 20532 Da
Additional Information
Gene ID 27113
Other Names BBC3
Dilution WB~~1/500-1/1000
IHC~~1/50-1/100
IF~~1/50-1/200
Format Liquid
Protein Information
Name BBC3
Synonyms PUMA
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity).
Cellular Location Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)
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$ 385.00
Cat# AP75977
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Ordering Information

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