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NARS2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q96I59 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54090 Da |
| Antigen Region | 445-474 aa |
| Gene ID | 79731 |
|---|---|
| Other Names | Probable asparagine--tRNA ligase, mitochondrial, Asparaginyl-tRNA synthetase, AsnRS, NARS2 |
| Target/Specificity | This NARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human NARS2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NARS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NARS2 (HGNC:26274) |
|---|---|
| Function | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis (PubMed:25385316). The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (Probable). |
| Cellular Location | Mitochondrion matrix. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
Asparagine-tRNA ligase (EC 6.1.1.22) catalyzes the chemical reaction: ATP + L-asparagine + tRNAAsn <---> AMP + diphosphate + L-asparaginyl-tRNAAsn. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis.
References
Bonnefond,L., Biochemistry 44 (12), 4805-4816 (2005)
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