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IGFBP2 Rabbit mAb
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- BACKGROUND
Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | P18065 |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 34814 Da |
| Gene ID | 3485 |
|---|---|
| Other Names | IGFBP2 |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | IGFBP2 |
|---|---|
| Synonyms | BP2, IBP2 |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). |
| Cellular Location | Secreted |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75599
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