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HOPX Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q8R1H0 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 8282 Da |
| Gene ID | 74318 |
|---|---|
| Other Names | Hopx |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | Hopx |
|---|---|
| Synonyms | Hod, Hop, Ob1 |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=According to PubMed:14516659 it is cytoplasmic. |
| Tissue Location | Expressed in the embryonic and adult heart and in the adult brain, liver, lung, skeletal muscle, intestine and spleen Throughout embryonic and postnatal development, it is expressed in the myocardium. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP75567
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