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HMGCR Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P04035 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 97476 Da |
| Gene ID | 3156 |
|---|---|
| Other Names | HMGCR |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | HMGCR (HGNC:5006) |
|---|---|
| Function | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347} |
| Tissue Location | [Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75556
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