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FKBP51 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q13451 |
| Reactivity | Hamster |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 51212 Da |
| Gene ID | 2289 |
|---|---|
| Other Names | FKBP5 |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | FKBP5 |
|---|---|
| Synonyms | AIG6, FKBP51 {ECO:0000303|PubMed:2814727 |
| Function | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q64378}. Nucleus {ECO:0000250|UniProtKB:Q64378} |
| Tissue Location | Widely expressed, enriched in testis compared to other tissues |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75440
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