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Fas Rabbit mAb

     
  • WB - Fas Rabbit mAb AP75427
    detail
  • IHC - Fas Rabbit mAb AP75427
    detail
  • IF - Fas Rabbit mAb AP75427
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F, ICC
Primary Accession P25445
Reactivity Human
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 37732 Da
Additional Information
Gene ID 355
Other Names FAS
Dilution WB~~1/500-1/1000
IHC~~1/50-1/100
IF~~1/50-1/200
Format Liquid
Protein Information
Name FAS
Synonyms APT1, FAS1, TNFRSF6
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Cellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft [Isoform 3]: Secreted. [Isoform 5]: Secreted.
Tissue Location Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Research Areas
Citations (0)
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$ 350.00
Cat# AP75427
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