ERCC1 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, ICC |
---|---|
Primary Accession | P07992 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 32562 Da |
Gene ID | 2067 |
---|---|
Other Names | ERCC1 |
Dilution | WB~~1/500-1/1000 IF~~1/50-1/200 |
Format | Liquid |
Name | ERCC1 |
---|---|
Function | [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. |
Cellular Location | [Isoform 1]: Nucleus [Isoform 3]: Nucleus |
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