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CDK3 Antibody (N-term Y19)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q00526 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35046 Da |
| Antigen Region | 4-38 aa |
| Gene ID | 1018 |
|---|---|
| Other Names | Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3 |
| Target/Specificity | This CDK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-38 amino acids from the N-terminal region of human CDK3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDK3 Antibody (N-term Y19) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDK3 |
|---|---|
| Synonyms | CDKN3 |
| Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Tissue Location | Expressed in cancer cell lines and glioblastoma tissue. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
References
Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).
Meyerson, M., et al., EMBO J. 11(8):2909-2917 (1992).
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