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RBM3 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P98179 |
| Other Accession | Q925G0, O89086 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17170 Da |
| Antigen Region | 128-157 aa |
| Gene ID | 5935 |
|---|---|
| Other Names | Putative RNA-binding protein 3, RNA-binding motif protein 3, RNPL, RBM3, RNPL |
| Target/Specificity | This RBM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the C-terminal region of human RBM3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RBM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBM3 |
|---|---|
| Synonyms | RNPL |
| Function | Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Cell projection, dendrite. Note=Localizes in mRNA granules in dentrites. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RBM3 is a member of the glycine-rich RNA-binding protein family and a protein with one RNA recognition motif (RRM) domain. Expression of this protein is induced by cold shock and low oxygen tension.
References
Zeng,Y., J. Cell. Biochem. 107 (1), 179-188 (2009)
Sureban,S.M., Oncogene 27 (33), 4544-4556 (2008)
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