GGTLA1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P36269 |
Other Accession | Q9Z2A9 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 62261 Da |
Antigen Region | 130-156 aa |
Gene ID | 2687 |
---|---|
Other Names | Gamma-glutamyltransferase 5, GGT 5, Gamma-glutamyl transpeptidase-related enzyme, GGT-rel, Gamma-glutamyltransferase-like activity 1, Gamma-glutamyltranspeptidase 5, Glutathione hydrolase 5, Leukotriene-C4 hydrolase, Gamma-glutamyltransferase 5 heavy chain, Gamma-glutamyltransferase 5 light chain, GGT5, GGTLA1 |
Target/Specificity | This GGTLA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-156 amino acids from the N-terminal region of human GGTLA1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GGTLA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GGT5 |
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Synonyms | GGTLA1 |
Function | Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). |
Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9Z2A9}; Single- pass type II membrane protein {ECO:0000250|UniProtKB:Q9Z2A9} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of gamma-glutamyl transpeptidase enzymes. This enzyme consists of a heavy and a light chain, and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay gamma-glutamyl transpeptidase.
References
Heisterkamp,N., Hum. Genet. 123 (4), 321-332 (2008)
Enoiu,M., Free Radic. Biol. Med. 29 (9), 825-833 (2000)
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