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BTBD1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q9H0C5 |
| Other Accession | P58544 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52771 Da |
| Antigen Region | 295-322 aa |
| Gene ID | 53339 |
|---|---|
| Other Names | BTB/POZ domain-containing protein 1, Hepatitis C virus NS5A-transactivated protein 8, HCV NS5A-transactivated protein 8, BTBD1, C15orf1, NS5ATP8 |
| Target/Specificity | This BTBD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human BTBD1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BTBD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BTBD1 |
|---|---|
| Synonyms | C15orf1, NS5ATP8 |
| Function | Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). |
| Cellular Location | Cytoplasm. Note=Localizes to punctate or elongated cytoplasmic bodies. |
| Tissue Location | Ubiquitous; highest levels in testes, heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.
References
Pisani,D.F., Cabane,C. Cell Death Differ. 11 (11), 1157-1165 (2004)
Xu,L., Yang,L. Exp. Cell Res. 288 (1), 84-93 (2003)
Xu,L., Yang,L. BMC Genomics 3 (1), 1 (2002)
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