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LINGO1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • IHC - LINGO1 Antibody (N-term) AP7284a
    Immunohistochemical analysis of paraffin-embedded Human brain section using Pink1(Cat#RB8949). RB8949 was diluted at 1:400 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
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  • WB - LINGO1 Antibody (N-term) AP7284a
    Western blot analysis of LINGO1 (arrow) using rabbit polyclonal LINGO1 Antibody (N-term) (Cat.#AP7284a).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2) (Origene Technologies).
    detail
  • IHC-P - LINGO1 Antibody (N-term) AP7284a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 Antibody (N-term) (Cat.#AP7284a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q96FE5
Other Accession Q9D1T0, Q9N008, Q50L44
Reactivity Human
Predicted Chicken, Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 69876 Da
Antigen Region 62-92 aa
Additional Information
Gene ID 84894
Other Names Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A
Target/Specificity This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human LINGO1.
Dilution IHC~~1:400
WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLINGO1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LINGO1
Synonyms LERN1, LRRN6A
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9D1T0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0}
Tissue Location Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Research Areas
Citations (0)
citation

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Background

LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.

References

Inoue,H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)
Satoh,J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)
Mosyak,L., J. Biol. Chem. 281 (47), 36378-36390 (2006)
Mi,S., Nat. Neurosci. 7 (3), 221-228 (2004)

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$ 365.00
$ 140.00
Cat# AP7284a
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