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LINGO1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q96FE5 |
| Other Accession | Q9D1T0, Q9N008, Q50L44 |
| Reactivity | Human |
| Predicted | Chicken, Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 69876 Da |
| Antigen Region | 62-92 aa |
| Gene ID | 84894 |
|---|---|
| Other Names | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A |
| Target/Specificity | This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human LINGO1. |
| Dilution | IHC~~1:400 WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LINGO1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LINGO1 |
|---|---|
| Synonyms | LERN1, LRRN6A |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9D1T0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0} |
| Tissue Location | Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
References
Inoue,H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)
Satoh,J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)
Mosyak,L., J. Biol. Chem. 281 (47), 36378-36390 (2006)
Mi,S., Nat. Neurosci. 7 (3), 221-228 (2004)
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