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ADRB2 Antibody (T384)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ADRB2 Antibody (T384) AP7263F
    Western blot analysis of anti-ADRB2 Antibody (T384) (Cat.#AP7263f) in SK-BR-3 cell line lysates (35ug/lane). ADRB2 (arrow) was detected using the purified Pab.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P07550
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 46459 Da
Antigen Region 364-393 aa
Additional Information
Gene ID 154
Other Names Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2, ADRB2R, B2AR
Target/Specificity This ADRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human ADRB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADRB2 Antibody (T384) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRB2
Synonyms ADRB2R, B2AR
Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine.
Cellular Location Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) Activated receptors are also detected within the Golgi apparatus (PubMed:27481942).
Research Areas
Citations (0)
citation

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Background

ADRB2, beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This protein is intronless.

References

Kobilka B.K., Dixon R.A.F.Proc. Natl. Acad. Sci. U.S.A. 84:46-50(1987)
Emorine L.J., Marullo S.Proc. Natl. Acad. Sci. U.S.A. 84:6995-6999(1987)
Kobilka B.K., Frielle T.J. Biol. Chem. 262:7321-7327(1987)

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$ 365.00
$ 140.00
Cat# AP7263F
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