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SENP7 Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9BQF6 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 119658 Da |
| Gene ID | 57337 |
|---|---|
| Other Names | SENP7; KIAA1707; SSP2; SUSP2; Sentrin-specific protease 7; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | SENP7 {ECO:0000303|Ref.2, ECO:0000312|HGNC:HGNC:30402} |
|---|---|
| Function | Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full- length SUMO proteins to their mature forms.
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