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CABC1 Antibody (C-term D531)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NI60 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 71950 Da |
| Antigen Region | 516-545 aa |
| Gene ID | 56997 |
|---|---|
| Other Names | Chaperone activity of bc1 complex-like, mitochondrial, Chaperone-ABC1-like, 2711-, aarF domain-containing protein kinase 3, ADCK3, CABC1 |
| Target/Specificity | This CABC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human CABC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CABC1 Antibody (C-term D531) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COQ8A {ECO:0000303|PubMed:27499294, ECO:0000312|HGNC:HGNC:16812} |
|---|---|
| Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:21296186, PubMed:25498144, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). |
| Cellular Location | Mitochondrion. Membrane; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398} |
| Tissue Location | Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CABC1 is one of several proteins for which expression is induced by p53 expression. The S. pombe homolog, ABC1, is a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
References
Iiizumi, M., et al., Cancer Res. 62(5):1246-1250 (2002).
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