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Gasdermin C Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9BYG8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57692 Da |
| Gene ID | 56169 |
|---|---|
| Other Names | GSDMC; MLZE; Gasdermin-C; Melanoma-derived leucine zipper-containing extranuclear factor |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | GSDMC {ECO:0000303|PubMed:17350798, ECO:0000312|HGNC:HGNC:7151} |
|---|---|
| Function | [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. |
| Cellular Location | [Gasdermin-C]: Cytoplasm, cytosol |
| Tissue Location | Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).
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