Dab1 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF |
---|---|
Primary Accession | O75553 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 63775 Da |
Gene ID | 1600 |
---|---|
Other Names | DAB1; Disabled homolog 1 |
Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | DAB1 |
---|---|
Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P97318}. |
Tissue Location | Mainly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter molecule functioning in neural development. May regulate SIAH1 activity.
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