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FOSB Antibody (Center P137)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - FOSB Antibody (Center P137) AP6940c
    Anti-FOSBAntibody(CenterP137) at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 36 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • FC - FOSB Antibody (Center P137) AP6940c
    FOSB Antibody (Center P137)(Cat.#AP6940c) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession P53539
Other Accession P13346, D3ZLB7
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35928 Da
Antigen Region 122-149 aa
Additional Information
Gene ID 2354
Other Names Protein fosB, G0/G1 switch regulatory protein 3, FOSB, G0S3
Target/Specificity This FOSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human FOSB.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOSB Antibody (Center P137) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOSB
Synonyms G0S3
Function Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'- TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P13346}.
Tissue Location [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level).
Research Areas
Citations (0)
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Background

FosB interacts with Jun proteins enhancing their DNA binding activity.

References

Li,S., et.al., Hepatology 49 (4), 1194-1202 (2009)
Starr,J.M., et.al., Mech. Ageing Dev. 129 (12), 745-751 (2008)

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$ 365.00
$ 140.00
Cat# AP6940c
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