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FOSB Antibody (Center P137)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P53539 |
| Other Accession | P13346, D3ZLB7 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35928 Da |
| Antigen Region | 122-149 aa |
| Gene ID | 2354 |
|---|---|
| Other Names | Protein fosB, G0/G1 switch regulatory protein 3, FOSB, G0S3 |
| Target/Specificity | This FOSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human FOSB. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOSB Antibody (Center P137) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOSB |
|---|---|
| Synonyms | G0S3 |
| Function | Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'- TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P13346}. |
| Tissue Location | [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
FosB interacts with Jun proteins enhancing their DNA binding activity.
References
Li,S., et.al., Hepatology 49 (4), 1194-1202 (2009)
Starr,J.M., et.al., Mech. Ageing Dev. 129 (12), 745-751 (2008)
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$ 365.00
$ 140.00
Cat# AP6940c
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