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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > OTC Antibody (Center)
OTC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | P00480 |
| Other Accession | P00481, O19072, P11725, Q9N1U7, P84010 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Pig, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39935 Da |
| Antigen Region | 71-98 aa |
| Gene ID | 5009 |
|---|---|
| Other Names | Ornithine carbamoyltransferase, mitochondrial, Ornithine transcarbamylase, OTCase, OTC |
| Target/Specificity | This OTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids of human OTC. |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTC (HGNC:8512) |
|---|---|
| Function | Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:2556444, PubMed:6372096, PubMed:8112735). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2556444). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Mainly expressed in liver and intestinal mucosa. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia.
References
Hansmannel,F., et.al., Neurosci. Lett. 449 (1), 76-80 (2009)
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$ 365.00
$ 140.00
Cat# AP6928c
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