GNPAT Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
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Primary Accession | O15228 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 77188 Da |
Antigen Region | 654-680 aa |
Gene ID | 8443 |
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Other Names | Dihydroxyacetone phosphate acyltransferase, DAP-AT, DHAP-AT, Acyl-CoA:dihydroxyacetonephosphateacyltransferase, Glycerone-phosphate O-acyltransferase, GNPAT, DAPAT, DHAPAT |
Target/Specificity | This GNPAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-680 amino acids from the C-terminal region of human GNPAT. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GNPAT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GNPAT (HGNC:4416) |
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Function | Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology. |
Cellular Location | Peroxisome membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ES71}; Matrix side {ECO:0000250|UniProtKB:Q9ES71}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane {ECO:0000250|UniProtKB:Q9ES71} |
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Provided below are standard protocols that you may find useful for product applications.
Background
GNPAT is an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids.
References
Ofman,R., et.al., Biochem. Biophys. Res. Commun. 281 (3), 754-760 (2001)
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