GNAS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q5JWF2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 111025 Da |
Antigen Region | 640-667 aa |
Gene ID | 2778 |
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Other Names | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Adenylate cyclase-stimulating G alpha protein, Extra large alphas protein, XLalphas, GNAS, GNAS1 {ECO:0000303|PubMed:9707596} |
Target/Specificity | This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-667 amino acids from the Central region of human GNAS. |
Dilution | WB~~1:4000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GNAS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GNAS |
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Synonyms | GNAS1 {ECO:0000303|PubMed:9707596} |
Function | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity). |
Cellular Location | Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63803}. Apical cell membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms.
References
Liu,C., et.al., Eur Arch Otorhinolaryngol (2009)
Nishihara,E., et.al., Endocr. J. 56 (6), 791-798 (2009)
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