ECE-1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
---|---|
Primary Accession | P42892 |
Other Accession | P42893, Q4PZA2, P42891 |
Reactivity | Human, Mouse |
Predicted | Bovine, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 87164 Da |
Antigen Region | 392-419 aa |
Gene ID | 1889 |
---|---|
Other Names | Endothelin-converting enzyme 1, ECE-1, ECE1 |
Target/Specificity | This ECE-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-419 amino acids from the Central region of human ECE-1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ECE-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ECE1 |
---|---|
Function | Converts big endothelin-1 to endothelin-1. |
Cellular Location | Cell membrane; Single-pass type II membrane protein |
Tissue Location | All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney |

Provided below are standard protocols that you may find useful for product applications.
Background
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
References
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)

If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.