WSB2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9NYS7 |
Other Accession | O54929, Q0V8J1 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 45286 Da |
Antigen Region | 375-404 aa |
Gene ID | 55884 |
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Other Names | WD repeat and SOCS box-containing protein 2, WSB-2, CS box-containing WD protein, WSB2 |
Target/Specificity | This WSB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-404 amino acids from the C-terminal region of human WSB2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WSB2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WSB2 |
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Function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
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Provided below are standard protocols that you may find useful for product applications.
Background
WSB2 is a member of the WD-protein subfamily. This protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases.
References
Kile,B.T., et.al., Trends Biochem. Sci. 27 (5), 235-241 (2002)
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