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ASS Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC-P, FC, IHC-P-Leica, E |
|---|---|
| Primary Accession | P00966 |
| Other Accession | P09034, P16460 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46530 Da |
| Antigen Region | 192-221 aa |
| Gene ID | 445 |
|---|---|
| Other Names | Argininosuccinate synthase, Citrulline--aspartate ligase, ASS1, ASS |
| Target/Specificity | This ASS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the Central region of human ASS. |
| Dilution | IF~~1:25 WB~~1:2000 IHC-P~~1:25 IHC-P-Leica~~1:500 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASS1 (HGNC:758) |
|---|---|
| Function | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. |
| Cellular Location | Cytoplasm, cytosol |
| Tissue Location | Expressed in adult liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ASS catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase.
References
Engel,K., et.al., Hum. Mutat. 30 (3), 300-307 (2009)
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