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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TF Antibody (C-term)   

TF Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TF Antibody (C-term) AP6804b
    Western blot analysis of TF Antibody (C-term) (Cat. #AP6804b) in MCF7 cell line lysates (35ug/lane). TF (arrow) was detected using the purified Pab.
    detail
  • IHC-P - TF Antibody (C-term) AP6804b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with TF Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - TF Antibody (C-term) AP6804b
    TF Antibody (C-term) (Cat.#AP6804b) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, IHC-P, E
Primary Accession P02787
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 77050 Da
Antigen Region 627-654 aa
Additional Information
Gene ID 7018
Other Names Serotransferrin, Transferrin, Beta-1 metal-binding globulin, Siderophilin, TF
Target/Specificity This TF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-654 amino acids from the C-terminal region of human TF.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TF (HGNC:11740)
Function Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)
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Background

TF is a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.

References

Mason,A.B., et.al., Biochemistry 32 (20), 5472-5479 (1993)

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$ 365.00
$ 140.00
Cat# AP6804b
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