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GBAS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O75323 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33743 Da |
| Antigen Region | 130-159 aa |
| Gene ID | 2631 |
|---|---|
| Other Names | Protein NipSnap homolog 2, NipSnap2, Glioblastoma-amplified sequence, GBAS, NIPSNAP2 |
| Target/Specificity | This GBAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human GBAS. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GBAS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NIPSNAP2 {ECO:0000303|PubMed:30982665, ECO:0000312|HGNC:HGNC:4179} |
|---|---|
| Function | Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Widely expressed (PubMed:9615231). Most abundant in heart and skeletal muscle (PubMed:9615231) |
Provided below are standard protocols that you may find useful for product applications.
Background
Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor.The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle. GBAS protein might be involved in vesicular transport.
References
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Seroussi, E., et al. Gene 212(1):13-20(1998)
Wang, X.Y., et al. Genomics 49(3):448-451(1998)
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