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TOMM70A Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | O94826 |
| Other Accession | Q75Q39, Q9CZW5 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67455 Da |
| Antigen Region | 579-608 aa |
| Gene ID | 9868 |
|---|---|
| Other Names | Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70 |
| Target/Specificity | This TOMM70A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-608 amino acids from the C-terminal region of human TOMM70A. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TOMM70A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TOMM70 (HGNC:11985) |
|---|---|
| Function | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). |
| Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.
References
Blesa,J.R., Gene 427 (1-2), 58-64 (2008)
Chou,C.H., Mol. Biol. Cell 17 (9), 3952-3963 (2006)
Edmonson,A.M., Cell Commun. Adhes. 9 (1), 15-27 (2002)
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$ 182.50
$ 70.00
Cat# AP6745b
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