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BGN Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P21810 |
| Other Accession | P47853, P28653, P21809, O46403, O46390 |
| Reactivity | Human |
| Predicted | Bovine, Horse, Mouse, Rat, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41654 Da |
| Antigen Region | 148-176 aa |
| Gene ID | 633 |
|---|---|
| Other Names | Biglycan, Bone/cartilage proteoglycan I, PG-S1, BGN, SLRR1A |
| Target/Specificity | This BGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the Central region of human BGN. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BGN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BGN |
|---|---|
| Synonyms | SLRR1A |
| Function | May be involved in collagen fiber assembly. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Found in several connective tissues, especially in articular cartilages. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival.
References
Sardo,M.A., Clin. Chim. Acta 406 (1-2), 89-93 (2009)
Hwang,J.Y., Am. J. Pathol. 173 (6), 1919-1928 (2008)
Traupe,H., Genomics 13 (2), 481-483 (1992)
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