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P450R Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - P450R Antibody (Center) AP6518C
    Western blot analysis of P450R antibody (Center) (Cat.# AP6518c) in K562 cell line lysates (35ug/lane). P450R (arrow) was detected using the purified Pab.
    detail
  • IHC-P - P450R Antibody (Center) AP6518C
    P450R Antibody (Center) (Cat.# AP6518c) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the P450R Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession P16435
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 76690 Da
Antigen Region 462-488 aa
Additional Information
Gene ID 5447
Other Names NADPH--cytochrome P450 reductase, CPR, P450R, POR, CYPOR
Target/Specificity This P450R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-488 amino acids from the Central region of human P450R.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsP450R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POR {ECO:0000255|HAMAP-Rule:MF_03212}
Synonyms CYPOR
Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Cellular Location Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP- Rule:MF_03212}
Research Areas
Citations (0)
citation

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Background

P450R is an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in its gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

References

Fukami,M., J. Clin. Endocrinol. Metab. 94 (5), 1723-1731 (2009)
Mast,N., Arch. Biochem. Biophys. 483 (1), 81-89 (2009)
Brenner,S., FEBS J. 275 (18), 4540-4557 (2008)

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$ 365.00
$ 140.00
Cat# AP6518C
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