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AGXT Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P21549 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43010 Da |
| Antigen Region | 96-125 aa |
| Gene ID | 189 |
|---|---|
| Other Names | Serine--pyruvate aminotransferase, SPT, Alanine--glyoxylate aminotransferase, AGT, AGXT, AGT1, SPAT |
| Target/Specificity | This AGXT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the Central region of human AGXT. |
| Dilution | WB~~1:8000 IHC-P~~1:25 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AGXT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGXT (HGNC:341) |
|---|---|
| Synonyms | AGT1, SPAT |
| Function | Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:23229545, PubMed:24055001, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152). |
| Cellular Location | Peroxisome |
| Tissue Location | Liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
AGXT is expressed only in the liver and protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification.
References
Cellini,B., J. Biol. Chem. 284 (13), 8349-8358 (2009)
Bertoldi,M., Biochim. Biophys. Acta 1784 (9), 1356-1362 (2008)
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