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GABA Transporter 1 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P30531 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67074 Da |
| Gene ID | 6529 |
|---|---|
| Other Names | SLC6A1; GABATR; GABT1; GAT1; Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1 |
| Dilution | WB~~WB 1:1000-2000, IHC 1:100-200 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | SLC6A1 |
|---|---|
| Synonyms | GABATR, GABT1, GAT1 |
| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
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