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MAGEA4 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P43358 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34899 Da |
| Antigen Region | 9-38 aa |
| Gene ID | 4103 |
|---|---|
| Other Names | Melanoma-associated antigen 4, Cancer/testis antigen 14, CT14, MAGE-4 antigen, MAGE-41 antigen, MAGE-X2 antigen, MAGEA4, MAGE4 |
| Target/Specificity | This MAGEA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human MAGEA4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAGEA4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAGEA4 |
|---|---|
| Synonyms | MAGE4 |
| Function | Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486). |
| Tissue Location | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta |
Provided below are standard protocols that you may find useful for product applications.
Background
MAGEA4 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
References
Nagao, T., et al., J. Biol. Chem. 278(12):10668-10674 (2003).
Resnick, M.B., et al., Int. J. Cancer 101(2):190-195 (2002).
Imai, Y., et al., Gene 160(2):287-290 (1995).
Rogner, U.C., et al., Genomics 29(3):725-731 (1995).
De Plaen, E., et al., Immunogenetics 40(5):360-369 (1994).
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