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Anti-CD226 (pS329) Antibody
Rabbit polyclonal antibody to CD226 (pS329)
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- BACKGROUND
Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | Q15762 |
| Other Accession | Q8K4F0 |
| Reactivity | Human, Mouse, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38614 Da |
| Gene ID | 10666 |
|---|---|
| Other Names | DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226 |
| Target/Specificity | Recognizes endogenous levels of CD226 (pS329) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/200), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/50 - 1/200), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CD226 |
|---|---|
| Synonyms | DNAM1 |
| Function | Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus- infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. |
| Tissue Location | Expressed by peripheral blood T-lymphocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD226 (pS329). The exact sequence is proprietary.
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