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Anti-Caspase 9 (pS144) Antibody
Rabbit polyclonal antibody to Caspase 9 (pS144)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P55211 |
| Other Accession | Q8C3Q9 |
| Reactivity | Human, Mouse, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46281 Da |
| Gene ID | 842 |
|---|---|
| Other Names | MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6 |
| Target/Specificity | Recognizes endogenous levels of Caspase 9 (pS144) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CASP9 |
|---|---|
| Synonyms | MCH6 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage- induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758106, PubMed:36758105). |
| Tissue Location | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 9 (pS144). The exact sequence is proprietary.
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