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Anti-DAP Kinase 2 Antibody
Rabbit polyclonal antibody to DAP Kinase 2
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UIK4 |
| Other Accession | Q8VDF3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42898 Da |
| Gene ID | 23604 |
|---|---|
| Other Names | Death-associated protein kinase 2; DAP kinase 2; DAP-kinase-related protein 1; DRP-1 |
| Target/Specificity | Recognizes endogenous levels of DAP Kinase 2 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | DAPK2 |
|---|---|
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, autophagosome lumen |
| Tissue Location | Expressed in neutrophils and eosinophils (PubMed:24163421). Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DAP Kinase 2. The exact sequence is proprietary.
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