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Anti-IGFBP3 (pS183) Antibody
Rabbit polyclonal antibody to IGFBP3 (pS183)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P17936 |
| Reactivity | Human, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31674 Da |
| Gene ID | 3486 |
|---|---|
| Other Names | IBP3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3 |
| Target/Specificity | Recognizes endogenous levels of IGFBP3 (pS183) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | IGFBP3 |
|---|---|
| Synonyms | IBP3 |
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF- independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP- 1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). |
| Cellular Location | Secreted. Nucleus |
| Tissue Location | Expressed by most tissues. Present in plasma. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IGFBP3. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP61078
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