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Anti-FOSB (pS27) Antibody
Rabbit polyclonal antibody to FOSB (pS27)
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Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | P53539 |
| Other Accession | P13346 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35928 Da |
| Gene ID | 2354 |
|---|---|
| Other Names | G0S3; Protein fosB; G0/G1 switch regulatory protein 3 |
| Target/Specificity | Recognizes endogenous levels of FOSB (pS27) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/100), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/50 - 1/100), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | FOSB |
|---|---|
| Synonyms | G0S3 |
| Function | Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'- TGA[GC]TCA-3' and enhancing their transcriptional activity (PubMed:12618758, PubMed:28981703). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Exhibits transactivation activity in vitro (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P13346}. |
| Tissue Location | [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human FOSB. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP61074
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