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Anti-iNOS (pY151) Antibody
Rabbit polyclonal antibody to iNOS (pY151)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P35228 |
| Other Accession | P29477 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 131117 Da |
| Gene ID | 4843 |
|---|---|
| Other Names | NOS2A; Nitric oxide synthase inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2 |
| Target/Specificity | Recognizes endogenous levels of iNOS (pY151) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/100) E~~WB (1/500 - 1/1000), IH (1/50 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | NOS2 (HGNC:7873) |
|---|---|
| Synonyms | NOS2A |
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). |
| Cellular Location | Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. |
| Tissue Location | Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets Expressed in chondrocytes (PubMed:7504305) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human iNOS. The exact sequence is proprietary.
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$ 385.00
$ 175.00
Cat# AP60917
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