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Anti-UCP3 Antibody
Rabbit polyclonal antibody to UCP3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P55916 |
| Other Accession | P56501 |
| Reactivity | Human, Mouse, Rat, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34216 Da |
| Gene ID | 7352 |
|---|---|
| Other Names | SLC25A9; Mitochondrial uncoupling protein 3; UCP 3; Solute carrier family 25 member 9 |
| Target/Specificity | Recognizes endogenous levels of UCP3 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | UCP3 {ECO:0000303|PubMed:9180264, ECO:0000312|HGNC:HGNC:12519} |
|---|---|
| Function | Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:11171965, PubMed:12670931, PubMed:12734183, PubMed:9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458). |
| Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P56501}; Multi-pass membrane protein |
| Tissue Location | Only in skeletal muscle and heart (PubMed:9305858). Also expressed in white and brown adipose tissues (PubMed:9305858). Is more expressed in glycolytic than in oxidative skeletal muscles |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human UCP3. The exact sequence is proprietary.
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