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Anti-GPR56 Antibody
Rabbit polyclonal antibody to GPR56
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y653 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77738 Da |
| Gene ID | 9289 |
|---|---|
| Other Names | TM7LN4; TM7XN1; G-protein coupled receptor 56; Protein TM7XN1 |
| Target/Specificity | Recognizes endogenous levels of GPR56 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ADGRG1 (HGNC:4512) |
|---|---|
| Synonyms | GPR56, TM7LN4, TM7XN1 |
| Function | Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein [ADGRG1 C-terminal fragment]: Membrane raft. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts |
| Tissue Location | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR56. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP60464
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