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> home > Products > Primary Antibodies > Antibody Collections > SARS-Human interaction partners > Anti-SMAD2 (pS467) Antibody
Anti-SMAD2 (pS467) Antibody
Rabbit polyclonal antibody to SMAD2 (pS467)
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Application 
| WB, E, IF/IC, IHC |
|---|---|
| Primary Accession | Q15796 |
| Other Accession | Q62432 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Monkey, Pig, Chicken, Bovine, SARS |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52306 Da |
| Gene ID | 4087 |
|---|---|
| Other Names | MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 |
| Target/Specificity | Recognizes endogenous levels of SMAD2 (pS467) protein. |
| Dilution | WB~~E (1/5000 - 1/10000), WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IF~~E (1/5000 - 1/10000), WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) E~~E (1/5000 - 1/10000), WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SMAD2 |
|---|---|
| Synonyms | MADH2, MADR2 |
| Function | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:9865696} |
| Tissue Location | Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SMAD2 (pS467). The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP60396
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