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Anti-CRHR1 Antibody
Rabbit polyclonal antibody to CRHR1
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Application 
| WB |
|---|---|
| Primary Accession | P34998 |
| Other Accession | P35347 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47671 Da |
| Gene ID | 104909134;1394 |
|---|---|
| Other Names | CRFR; CRFR1; CRHR; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1 |
| Target/Specificity | Recognizes endogenous levels of CRHR1 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CRHR1 (HGNC:2357) |
|---|---|
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis |
| Tissue Location | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CRHR1. The exact sequence is proprietary.
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