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Anti-Caveolin 1 (pY14) Antibody
Rabbit polyclonal antibody to Caveolin 1 (pY14)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q03135 |
| Other Accession | P49817 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, SARS, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20472 Da |
| Gene ID | 857 |
|---|---|
| Other Names | CAV; Caveolin-1 |
| Target/Specificity | Recognizes endogenous levels of Caveolin 1 (pY14) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IP (1/10 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CAV1 |
|---|---|
| Synonyms | CAV |
| Function | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)- hydroxycholesterol (20(S)-OHC) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724} Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae |
| Tissue Location | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Caveolin 1 (pY14). The exact sequence is proprietary.
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$ 385.00
$ 175.00
Cat# AP59979
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