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Anti-Aldose Reductase Antibody
Rabbit polyclonal antibody to Aldose Reductase
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- CITATIONS
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- BACKGROUND
Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | P15121 |
| Other Accession | P45376 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35853 Da |
| Gene ID | 231 |
|---|---|
| Other Names | ALDR1; Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1 |
| Target/Specificity | Recognizes endogenous levels of Aldose Reductase protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AKR1B1 |
|---|---|
| Synonyms | ALDR1, ALR2 {ECO:0000303|PubMed:17368668 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS- carbonyls) (PubMed:21329684). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Aldose Reductase. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP59964
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